OHBOT for the brain
Storehouse

Don't take our word for it. Take the papers.

Every study cited on this site, as a PDF you can download, keep and read yourself. Grouped by strength of design. Nothing here is behind a claim you can't check.

9 papers All downloadable Peer-reviewed journals
Randomised controlled trials

The strongest test

↓
Weaver et al., 2025 — double-blind, sham-controlled RCT
Scientific Reports. Real HBO₂ beat sham on brain-injury symptoms (MD 7.0, 95% CI 1.7–12.3, p = 0.01).
↓
Harch et al., 2020 — randomised crossover, FDA IND #113823
Medical Gas Research. 63 subjects; gains in memory, mood, PTSD, sleep and quality of life, held at 2 months.
↓
Boussi-Gross et al., 2013 — randomised crossover
PLoS ONE. 56 patients, 1–5 yrs post mild-TBI; cognition & quality of life improved, SPECT-confirmed.
Meta-analysis, cohort & imaging

Pooled, large-scale and scan-anchored

↓
Shahid et al., 2025 — systematic review & meta-analysis
4 studies, 250 patients. Memory MD 10.13, attention MD 7.99 (both p < 0.00001), plus executive function, speed, motor skill.
↓
Hadanny et al., 2018 — retrospective cohort (n = 154)
BMJ Open. Largest chronic-TBI cohort of its kind; objective cognitive testing and metabolic brain imaging.
↓
Harch et al., 2017 — case-control with SPECT (n = 30)
Medical Gas Research. Veterans with PCS + PTSD; SPECT normalised in 75% of abnormal regions; reduced suicidal ideation.
Mechanism reviews & adjacent injury

Why it should work, and the stroke case

↓
Gottfried, Schottlender & Ashery, 2021 — mechanism review
Biomolecules. How HBOT raises tissue oxygen and drives cellular repair — mitochondria, oxidative stress, inflammation.
↓
Bin-Alamer et al., 2024 — mechanism review
Frontiers in Neurology. Recovery via mitochondrial biogenesis, neurogenesis, synaptogenesis and angiogenesis.
↓
Ding et al., 2014 — review, ischaemic stroke
Interventional Neurology. Neuroprotective mechanisms; the 2013 FDA arterial-occlusion indication; open questions of dose & timing.

Note: the meta-analysis (Shahid 2025) is a peer-reviewed systematic review; its host journal is recorded in the file metadata. All PDFs are the authors' published versions, provided here for study and personal reference.

Accepted-indication references

HBOT as it's already used

The brain application is the new frontier — but HBOT is long-established standard care for a defined set of conditions. These references document the accepted indications.

U
UHMS — Approved indications for hyperbaric oxygen
The Undersea & Hyperbaric Medical Society's authoritative list of accepted conditions.
F
FDA — Hyperbaric Oxygen Therapy: Get the Facts
The regulator's consumer guidance, including the cleared indications and cautions.
P
PubMed — HBOT & traumatic brain injury
Search the primary literature, including every trial cited on this site.
Full directory of sources Back to the evidence